How-To Disable And Clear Auto-Complete Cache In Outlook 2010
The Outlook 2010 Auto-Complete suggestions / cache functions just like it did in Outlook 2007, and just like before we’re going to show you how to disable it. This time it’s a little different; easier to find, but still tricky if your still not up to speed on where Outlook 2010 moved all the options settings. Fortunately Microsoft caved in on the new Office Ribbon so our old friend Mr. File menu is back!
How To Disable the Outlook 2010 Auto-Complete and Clear the Auto-Complete Cache
1. In Outlook 2010, Click the File menu and Select Options.

2. In the Outlook Options window Click the Mail tab.

3. Scroll down roughly halfway until you see Send messages. Uncheck the Use Auto-Complete List to suggest names when typing in the To, Cc, and Bcc lines box.
Optional Step: To clear out the Auto-Complete list, simply Click the Empty Auto-Complete List button. That’s right, there is no .NK2 file you need to mess with like you did back in the Outlook 2003 / Outlook 2007 days.

4. You’ll see a confirmation window about clearing the Auto-Complete list, Click Yes.

Now Outlook Auto-Complete should be completely disabled and any history that was in the Auto-Complete list should be completely erased (if you clicked the clear auto complete button). Mission accomplished!